Using Causal Methods to Evaluate the Role of Biomarkers Advanced Psychometrics
Methods in Cognitive Aging Research Workshop 


   Note: An Official Proposal has not been Submitted to NACC.


   Lead Investigator:    Laura Gibbons
   Institution      :    U Washington
   E-Mail           :    gibbonsl@uw.edu
   Proposal ID      :    1713



   Proposal Description:
   The biomarker studies that have generated much of the knowledge base about amyloid and vascular mechanisms for cognitive decline and dementia have typically utilized highly selected samples, raising a fundamental question about whether these findings apply to broader populations. Understanding how sampling bias affects substantive knowledge about processes and mechanisms of cognitive decline is critical for developing an empirical knowledge base about late life cognitive decline that encompasses the rapidly growing and increasingly diverse older population. A set of methods available to help transport associations between data sets will be applied to determine how ADNI MRI and PET biomarkers might generalize to the US population.